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Research Plan:  Make the Most of Your Significance, Innovation, Approach and Overall Impact

Probably the most important parts of your National Institutes of Health (NIH) R01 application are those in which you describe your proposed research. In particular, these are the Specific Aims and Research Strategy sections. They address your project’s Significance, Innovation and Approach, which are three of the five core grant criteria that reviewers use to score your application. As a matter of fact, these sections are the ones you will spend most of your writing time on.

At the same time, these sections will heavily influence your application’s Overall Impact score. Unfortunately, there is no template for incorporating overall impact into your application, and there is no section called “Overall Impact” — or even an incentive to simply add a paragraph labeled as such.

Consequently, this report examines how you can use the Specific Aims and Research Strategy to perform double-duty:

  • Fulfill the Significance, Innovation and Approach criteria
  • Support the Overall Impact of your research

Must-have, step-by-step expert guidance includes:

  • Avoid the dreaded “overly ambitious” reviewers’ critique with advice from the experts
  • Are your Specific Aims “sequential” or “parallel”? 1 Way to know for sure
  • One section holds the key to completing the rest of your application. Learn the easiest place to start
  • How to make the argument that your research is “translational” — Key language every grant-writer should know
  • Effectively craft your Innovation section: Here’s how
  • Reviewers focus specifically on your Approach — Make sure yours passes muster
  • How much preliminary data is really necessary? Know where to draw the line

PLUS! This 53-pg special report includes sample language from NIH funded applications specifically focused on these sections!

SUMMER BLOWOUT SALE: Purchase this Special Report in digital (PDF) format at the special rate of $79 (reg. price $199). For a print version, please add $20 more.

This Special Report is a part of the "NIH R01 Grant Application" Mentor: An Instructional Manual. See below for more information.

"NIH R01 Grant Application" Mentor: An Instructional Manual

This unique manual coaches you on how to optimally prepare the vital components of your R01 grant application in full compliance with the new rules and formats.

Limited-Time Offer!

Purchase the entire manual in PDF format for only $399 (reg. price $599). The manual includes all sections highlighted below. Or, choose only the individual sections
you need for $79 each.

The Manual includes the below sections:

  • Section 1: Preparation: What Every PI Should Know Before You Start Applying
  • Section 2: Successfully Use Your Biosketch and Abstract to Define Your Project and Your Qualifications
  • Section 3: Prove Your Environment Supports Your Research
  • Section 4: Research Plan: Make the Most of Your Significance, Innovation, Approach and Overall Impact
  • Section 5: Modular and Detailed Budget Strategies That Support Your Proposal
  • Section 6: Tactics for Submitting a Winning Proposal
  • Section 7: Understand NIH's Review Process and Your Role in It

For more detailed information on this NIH R01 Manual, please click here.

The informational products above are brought to you as training tools by the Principal Investigators Association, which is an independent organization. The products presented and their contents are not connected with the National Institutes of Health (NIH) or the National Science Foundation (NSF), nor are they endorsed by these agencies. All views expressed are those personally held by the author and are not official government policies or opinions.